| Southern Methodist University | Dallas, TX | University | Private nonprofit |
| Southern Nazarene University | Bethany, OK | University | Private nonprofit |
| Southern New Hampshire University | Manchester, NH | University | Private nonprofit |
| Southern Oregon University | Ashland, OR | University | Public |
| Southern Regional Technical College | Thomasville, GA | College | Public |
| Southern State Community College | Hillsboro, OH | College | Public |
| Southern Union State Community College | Wadley, AL | College | Public |
| Southern University Law Center | Baton Rouge, LA | Graduate school | Public |
| Southern University and A & M College | Baton Rouge, LA | University | Public |
| Southern University at New Orleans | New Orleans, LA | University | Public |
| Southern University at Shreveport | Shreveport, LA | College | Public |
| Southern University-Board and System | Baton Rouge, LA | University | Public |
| Southern Utah University | Cedar City, UT | University | Public |
| Southern Virginia University | Buena Vista, VA | College | Private nonprofit |
| Southern Wesleyan University | Central, SC | University | Private nonprofit |
| Southern West Virginia Community and Technical College | Logan, WV | College | Public |
| Southside College of Health Sciences | Colonial Heights, VA | College | Private nonprofit |
| Southside Virginia Community College | Alberta, VA | College | Public |
| Southwest Baptist University | Bolivar, MO | University | Private nonprofit |
| Southwest College for the Deaf | Big Spring, TX | College | Public |
| Southwest Minnesota State University | Marshall, MN | University | Public |
| Southwest Mississippi Community College | Summit, MS | College | Public |
| Southwest Tennessee Community College | Memphis, TN | College | Public |
| Southwest Texas College | Uvalde, TX | College | Public |
| Southwest Virginia Community College | Cedar Bluff, VA | College | Public |