| Southeast New Mexico College | Carlsbad, NM | College | Public |
| Southeast Technical College | Sioux Falls, SD | College | Public |
| Southeastern Baptist College | Laurel, MS | College | Private nonprofit |
| Southeastern Baptist Theological Seminary | Wake Forest, NC | University | Private nonprofit |
| Southeastern Community College | Whiteville, NC | College | Public |
| Southeastern Community College | West Burlington, IA | College | Public |
| Southeastern Free Will Baptist Bible College | Wendell, NC | College | Private nonprofit |
| Southeastern Illinois College | Harrisburg, IL | College | Public |
| Southeastern Louisiana University | Hammond, LA | University | Public |
| Southeastern Oklahoma State University | Durant, OK | University | Public |
| Southeastern Technical College | Vidalia, GA | College | Public |
| Southeastern University | Lakeland, FL | University | Private nonprofit |
| Southern Adventist University | Collegedale, TN | University | Private nonprofit |
| Southern Arkansas University Main Campus | Magnolia, AR | University | Public |
| Southern Arkansas University Tech | Camden, AR | College | Public |
| Southern California Institute of Architecture | Los Angeles, CA | University | Private nonprofit |
| Southern California Seminary | El Cajon, CA | University | Private nonprofit |
| Southern California University of Health Sciences | Whittier, CA | University | Private nonprofit |
| Southern College of Optometry | Memphis, TN | Graduate school | Private nonprofit |
| Southern Connecticut State University | New Haven, CT | University | Public |
| Southern Crescent Technical College | Griffin, GA | College | Public |
| Southern Illinois University Edwardsville | Edwardsville, IL | University | Public |
| Southern Illinois University-Carbondale | Carbondale, IL | University | Public |
| Southern Illinois University-System Office | Carbondale, IL | University | Public |
| Southern Maine Community College | South Portland, ME | College | Public |