| South Baylo University | Anaheim, CA | Graduate school | Private nonprofit |
| South Carolina State University | Orangeburg, SC | University | Public |
| South Central College | North Mankato, MN | College | Public |
| South Dakota School of Mines and Technology | Rapid City, SD | University | Public |
| South Dakota State University | Brookings, SD | University | Public |
| South Florida Bible College and Theological Seminary | Deerfield Beach, FL | University | Private nonprofit |
| South Florida State College | Avon Park, FL | College | Public |
| South Georgia State College | Douglas, GA | College | Public |
| South Georgia Technical College | Americus, GA | College | Public |
| South Louisiana Community College | Lafayette, LA | College | Public |
| South Mountain Community College | Phoenix, AZ | College | Public |
| South Orange County Community College District | Mission Viejo, CA | College | Public |
| South Piedmont Community College | Polkton, NC | College | Public |
| South Plains College | Levelland, TX | College | Public |
| South Puget Sound Community College | Olympia, WA | College | Public |
| South Seattle College | Seattle, WA | College | Public |
| South Suburban College | South Holland, IL | College | Public |
| South Texas College | McAllen, TX | College | Public |
| South Texas College of Law Houston | Houston, TX | Graduate school | Private nonprofit |
| Southcentral Kentucky Community and Technical College | Bowling Green, KY | College | Public |
| Southeast Arkansas College | Pine Bluff, AR | College | Public |
| Southeast Community College Area | Lincoln, NE | College | Public |
| Southeast Kentucky Community & Technical College | Cumberland, KY | College | Public |
| Southeast Missouri Hospital College of Nursing and Health Sciences | Cape Girardeau, MO | College | Private nonprofit |
| Southeast Missouri State University | Cape Girardeau, MO | University | Public |